The multiple modes of action of propafenone.

@article{Dukes1984TheMM,
  title={The multiple modes of action of propafenone.},
  author={Iain D. Dukes and E. M. VAUGHAN WILLIAMS},
  journal={European heart journal},
  year={1984},
  volume={5 2},
  pages={
          115-25
        }
}
Previous studies of widely different concentrations of propafenone in various species have reported that in addition to having class 1 antiarrhythmic action, the drug was a beta adrenoceptor blocker and a calcium antagonist. High concentration shortened action potential duration in animal experiments, but Q-T interval was reported as being lengthened in man. It was thought desirable to study the effects of propafenone over a range of concentrations equivalent to those used clinically in various… CONTINUE READING
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