The multiple functions of HIV-1 Tat: proliferation versus apoptosis.

  title={The multiple functions of HIV-1 Tat: proliferation versus apoptosis.},
  author={Francesca Peruzzi},
  journal={Frontiers in bioscience : a journal and virtual library},
  • Francesca Peruzzi
  • Published 2006 in
    Frontiers in bioscience : a journal and virtual…
The HIV-1 transactivating factor Tat plays critical roles in the pathogenesis of AIDS. Originally discovered as a potent activator of viral replication, Tat has now been found to be involved in the regulation of both viral and cellular gene expression. Due to its structure, Tat protein can be secreted by infected cells, and can penetrate neighboring uninfected cells, altering their function in the absence of viral replication. Indeed, increasing number of reports suggest a multifunctional… CONTINUE READING

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Gelbard : HIV - 1 Transactivator of Transcription Protein Induces Mitochondrial Hyperpolarization and Synaptic Stress Leading to Apoptosis

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Dubiel : HIV - 1 tat inhibits the 20 S proteasome and its 11 S regulatormediated activation

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