The multiple facets of the intra-S checkpoint.

  title={The multiple facets of the intra-S checkpoint.},
  author={Be{\'a}ta Grallert and Erik Boye},
  journal={Cell cycle},
  volume={7 15},
In response to hydroxyurea treatment or DNA damage the total rate of DNA replication per cell is reduced. This reduction may be due to physical hindrance of the replication forks or to active, checkpoint-dependent processes. Here we review current knowledge about how and to what extent the intra-S checkpoint affects DNA replication. We discuss evidence that… CONTINUE READING