The multiple faces of caveolae

  title={The multiple faces of caveolae},
  author={Robert G. Parton and Kai Simons},
  journal={Nature Reviews Molecular Cell Biology},
Caveolae are a highly abundant but enigmatic feature of mammalian cells. They form remarkably stable membrane domains at the plasma membrane but can also function as carriers in the exocytic and endocytic pathways. The apparently diverse functions of caveolae, including mechanosensing and lipid regulation, might be linked to their ability to respond to plasma membrane changes, a property that is dependent on their specialized lipid composition and biophysical properties. 

The biology of caveolae: achievements and perspectives.

  • M. Parat
  • Biology
    International review of cell and molecular biology
  • 2009

Role of the Endocytosis of Caveolae in Intracellular Signaling and Metabolism.

Caveolae are 60-80 nm invaginated plasma membrane (PM) nanodomains, with a specific lipid and protein composition, which assist and regulate multiple processes in the plasma membrane-ranging from the

Caveolae at a glance

The plasma membrane is more than a simple delimitation of the boundary of the cell but is a dynamic multi-domain membrane system participating in numerous cellular processes. In many different cell

Caveolin-1: a new locus for human lipodystrophy.

Caveolae are specialized plasma membrane microdomains appearing as 50- to 100-nm vesicular invaginations rich in cholesterol, glycosphingolipids, and signaling proteins, especially caveolins, and three members of this family have been identified.

Cavin proteins: New players in the caveolae field.

Caveolae as plasma membrane sensors, protectors and organizers

The importance of caveolae as protective elements in the plasma membrane, and as membrane organizers and sensors, is highlighted by links between Caveolae dysfunction and human diseases, including muscular dystrophies and cancer.

Cholesterol, regulated exocytosis and the physiological fusion machine.

This work reviews and integrates the current literature on protein and lipid roles in exocytosis, with emphasis on the multiple roles of cholesterol in exocytes and membrane fusion, in an effort to promote a more molecular systems-level view of the as yet poorly understood process of Ca2+-triggered membrane mergers.



Membrane microdomains and caveolae.

Caveolae, transmembrane signalling and cellular transformation.

Existing evidence that suggests a role for caveolae in signalling events is discussed, including the identification of caveolin--a transformation-dependent v-Src substrate and caveolar marker protein--and the isolation of Caveolin-rich membrane domains from cultured cells.

Caveolae/raft-dependent endocytosis

It is proposed that caveolae and rafts are internalized via a common pathway, Caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, and sensitivity to cholesterol depletion.

Caveolae and intracellular trafficking of cholesterol.

VIP21/caveolin is a cholesterol-binding protein.

Findings suggest that VIP21/caveolin, through its cholesterol-binding properties, serves a specific function in microdomain formation during membrane trafficking in caveolae and apical transport vesicles.

Reduction of caveolin and caveolae in oncogenically transformed cells.

Observations suggest that functional alterations in caveolae may play a critical role in oncogenic transformation, perhaps by disrupting contact inhibition in transformed cells.

M‐caveolin, a muscle‐specific caveolin‐related protein

De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

The results show that VIP21-caveolin is a key structural component required for caveolar biogenesis and appears homogeneous in size and morphologically indistinguishable from caveolae of nonlymphoid cells.