The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences.

@article{Mottram1997TheMC,
  title={The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences.},
  author={Jeremy C Mottram and Mhairi J. Frame and Darren R Brooks and Laurence Tetley and James E Hutchison and Andre L. Souza and Graham H. Coombs},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 22},
  pages={14285-93}
}
The cpb genes of Leishmania mexicana encode stage-regulated, cathepsin L-like cysteine proteinases that are leishmanial virulence factors. Field inversion gel electrophoresis and genomic mapping indicate that there are 19 cpb genes arranged in a tandem array. Five genes from the array have been sequenced and their expression analyzed. The first two genes, cpb1 and cpb2, differ significantly from the remaining 17 copies (cpb3-cpb19) in that: 1) they are expressed predominantly in metacyclic… CONTINUE READING

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