The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls colony-stimulating factor-1 messenger RNA stability in ovarian cancer.

@article{Zhou2008TheMP,
  title={The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls colony-stimulating factor-1 messenger RNA stability in ovarian cancer.},
  author={Yi Zhou and Xiaofang Yi and Jha'nae B Stoffer and Nathalie Bonaf{\'e} and Maureen Gilmore-Hebert and Jessica McAlpine and Setsuko K. Chambers},
  journal={Molecular cancer research : MCR},
  year={2008},
  volume={6 8},
  pages={1375-84}
}
Although glyceraldehyde-3-phosphate dehydrogenase's (GAPDH) predilection for AU-rich elements has long been known, the expected connection between GAPDH and control of mRNA stability has never been made. Recently, we described GAPDH binding the AU-rich terminal 144 nt of the colony-stimulating factor-1 (CSF-1) 3' untranslated region (UTR), which we showed to be an mRNA decay element in ovarian cancer cells. CSF-1 is strongly correlated with the poor prognosis of patients with ovarian cancer. We… CONTINUE READING
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