The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

@article{Hidalgo2013TheMC,
  title={The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.},
  author={Carlos G. Hidalgo and Charles S Chung and Chandra Saripalli and Mei Methawasin and Kirk R. Hutchinson and George Tsaprailis and Siegfried Labeit and Alicia R. Mattiazzi and Henk L. M. Granzier},
  journal={Journal of molecular and cellular cardiology},
  year={2013},
  volume={54},
  pages={90-7}
}
Titin-based passive stiffness is post-translationally regulated by several kinases that phosphorylate specific spring elements located within titin's elastic I-band region. Whether titin is phosphorylated by calcium/calmodulin dependent protein kinase II (CaMKII), an important regulator of cardiac function and disease, has not been addressed. The aim of this work was to determine whether CaMKIIδ, the predominant CaMKII isoform in the heart, phosphorylates titin, and to use phosphorylation… CONTINUE READING

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