The multifactorial role of neutrophils in rheumatoid arthritis

  title={The multifactorial role of neutrophils in rheumatoid arthritis},
  author={H L Wright and Robert J. Moots and S W Edwards},
  journal={Nature Reviews Rheumatology},
Of all cells implicated in the pathology of rheumatoid arthritis (RA), neutrophils possess the greatest cytotoxic potential, owing to their ability to release degradative enzymes and reactive oxygen species. Neutrophils also contribute to the cytokine and chemokine cascades that accompany inflammation, and regulate immune responses via cell–cell interactions. Emerging evidence suggests that neutrophils also have a previously unrecognised role in autoimmune diseases: neutrophils can release… CONTINUE READING
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a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

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