The multifaceted role of the intestinal microbiota in colon cancer.

@article{Irrazbal2014TheMR,
  title={The multifaceted role of the intestinal microbiota in colon cancer.},
  author={Thergiory Irraz{\'a}bal and Antoaneta Belcheva and Stephen E. Girardin and Alberto Mart{\'i}n and Dana J Philpott},
  journal={Molecular cell},
  year={2014},
  volume={54 2},
  pages={309-20}
}
In recent years, our understanding of the mechanisms underlying colorectal carcinogenesis has vastly expanded. Underlying inflammation within the intestine, diet, and most recently, the gut microbiota, have been demonstrated to influence the development of colorectal cancer. However, since cancer is ultimately a genetic disease, these factors are thought to create genotoxic stress within the intestinal environment to promote genetic and epigenetic alterations leading to cancer. In this review… CONTINUE READING
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