The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

@article{Siegel2000TheMR,
  title={The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity},
  author={Richard M. Siegel and Francis Ka-Ming Chan and Hyung J. Chun and Michael J. Lenardo},
  journal={Nature Immunology},
  year={2000},
  volume={1},
  pages={469-474}
}
Originally identified as a cell surface receptor that triggered the death of lymphocytes and tumor cells, it is now recognized that Fas (also known as CD95 or Apo-1) has distinct functions in the life and death of different cell types in the immune system. Fas signaling may also be involved in T cell costimulation and proliferation. Although Fas deficiency in humans and mice predisposes them towards systemic autoimmunity, Fas-FasL interactions can also facilitate organ-specific immunopathology… 
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