The multifaceted mineralocorticoid receptor.

  title={The multifaceted mineralocorticoid receptor.},
  author={Elise P Gomez-Sanchez and Celso Enrique Gomez-Sanchez},
  journal={Comprehensive Physiology},
  volume={4 3},
The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol and corticosterone, act through the structurally similar mineralocorticoid (MR) and glucocorticoid receptors (GRs). Aldosterone is crucial for fluid, electrolyte, and hemodynamic homeostasis and tissue repair; the significantly more abundant glucocorticoids are indispensable for energy homeostasis, appropriate responses to stress, and limiting inflammation. Steroid receptors initiate gene transcription… CONTINUE READING
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