The multifaceted mast cell in inflammatory bowel disease.

  title={The multifaceted mast cell in inflammatory bowel disease.},
  author={Matthew J. Hamilton and Sandra Michaela Frei and Richard L. Stevens},
  journal={Inflammatory bowel diseases},
  volume={20 12},
Mast cells (MCs) are tissue-resident immune cells that carry out protective roles against pathogens. In disease states, such as inflammatory bowel disease, these granulocytes release a diverse array of mediators that contribute to inflammatory processes. They also participate in wound repair and tissue remodeling. In this review, the composition of MCs and how their phenotypes can be altered during inflammation of the gastrointestinal tract is detailed. Animal and human clinical studies that… CONTINUE READING


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