The multifaceted and widespread pathology of magnesium deficiency.

@article{Johnson2001TheMA,
  title={The multifaceted and widespread pathology of magnesium deficiency.},
  author={S Johnson},
  journal={Medical hypotheses},
  year={2001},
  volume={56 2},
  pages={
          163-70
        }
}
  • S. Johnson
  • Published 1 February 2001
  • Medicine
  • Medical hypotheses
Even though Mg is by far the least abundant serum electrolyte, it is extremely important for the metabolism of Ca, K, P, Zn, Cu, Fe, Na, Pb, Cd, HCl, acetylcholine, and nitric oxide (NO), for many enzymes, for the intracellular homeostasis and for activation of thiamine and therefore, for a very wide gamut of crucial body functions. Unfortunately, Mg absorption and elimination depend on a very large number of variables, at least one of which often goes awry, leading to a Mg deficiency that can… 

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References

SHOWING 1-10 OF 21 REFERENCES

Selenium deficiency as a cause of overload of iron and unbalanced distribution of other minerals.

TLDR
The results suggest that Se deficiency may cause a secondary overload of iron and unbalanced distribution of other minerals.

Effect of vitamin D treatment in hypoparathyroid patients: a study on calcium, phosphate and magnesium homeostasis.

TLDR
Vitamin D treatment apparently normalized the abnormalities previously found in phosphate homeostasis of hypoparathyroid patients, and resulted in a positive calcium balance and bone turnover was very low, implying a state of magnesium deficiency in these patients.

Tissue minerals of magnesium-deficient rats with thiamine deficiency and excess.

TLDR
It can be presumed thatThiamine deficiency inhibits magnesium depletion and, consequently, the influence of magnesium deficiency is less significant in the thiamine- and magnesium-deficient animals.

[New drugs with positive effects on bones].

TLDR
The nontraditional treatment of osteoporosis using endogenous substances regulating bone metabolism, and also new drugs, is concerned, and Mutual interactions with classical osteoprotic drugs remain to be established.

Parathyroid hormone increases bone formation and improves mineral balance in vitamin D-deficient female rats.

TLDR
Results indicate that mineral supply, more than vitamin D itself, may be important for normal bone mineralization and to enable PTH to enhance bone formation and that short term PTH treatment is anabolic in bone of vitamin D-deficient rats when adequate mineral amounts are provided in the diet.

Aggravation of thiamine deficiency by magnesium depletion. A case report.

TLDR
A patient with Crohn's disease and long-standing diarrhea resulting in a combined thiamine and magnesium deficiency is presented, and the dependence of thienine on magnesium for an adequate function in the body is emphasized.

Plasma (total and ionized), erythrocyte and platelet magnesium levels in renal transplant recipients during cyclosporine and/or azathioprine treatment.

TLDR
Both intraplatelet magnesium depletion and ionized plasma magnesium reduction induced by immunosuppressive therapy could be involved in the increased risk from atherosclerotic disease in renal transplant recipients.

Trace element concentrations in hair from autistic children.

TLDR
Evidence suggests that hair analysis may have potential use as a diagnostic tool for autism, and results indicate that the concentrations of trace elements in hair from normal children differ from patterns observed in both autistic and autistic-like children.

Attention deficit hyperactivity disorder, infantile autism, and elevated blood-lead: a possible relationship.

TLDR
The interaction and possible casual relationship of an elevated blood-lead, autism, and ADHD as well as treatment of the behavioral symptoms are explored.