The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane.

@article{Garrigues2002TheMT,
  title={The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane.},
  author={Alexia Garrigues and Alexandre E Escargueil and St{\'e}phane Orlowski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 16},
  pages={10347-52}
}
P-glycoprotein (P-gp) is a plasma membrane ATP-binding cassette transporter, responsible for multidrug resistance in tumor cells. P-gp catalyzes the ATP hydrolysis-dependent efflux of numerous amphiphilic compounds of unrelated chemical structures. In the absence of any identified substrate, P-gp exhibits an apparently futile, basal ATPase activity. By using native membrane vesicles containing high amounts of P-gp, we show here that (i) this basal ATPase activity is tightly dependent on the… CONTINUE READING

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