The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells.

@article{Kim2002TheMR,
  title={The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells.},
  author={Min Kyoung Kim and Hēth R Turnquist and John Jackson and Magda K Sgagias and Ying Yan and Maokai Gong and M. Dean and John Graham Sharp and Kenneth H. Cowan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 1},
  pages={22-8}
}
The human ATP-binding cassette superfamily G (White) member 2 (ABCG2) gene and its murine homologue breast cancer resistance protein 1 (Bcrp1) are recently described ATP-binding cassette transporters associated with drug resistance in tumor cell lines, including the MCF-7 cell line, selected for its resistance to mitoxantrone (MCF-7/MitoR). Infection of MCF-7 cells with the retroviral vector containing ABCG2 cDNA (G1-ABCG2) resulted in cells (MCF-7/ABCG2) that were resistant to mitoxantrone at… CONTINUE READING

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High-Dose Cancer Therapy: Pharmacology. Hematopoietics, Stem Cells. Pharmacologic Strategies for High-Dose Therapy

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