The multidrug resistance phenotype.

@article{Kaye1988TheMR,
  title={The multidrug resistance phenotype.},
  author={Stanley B. Kaye},
  journal={British Journal of Cancer},
  year={1988},
  volume={58},
  pages={691 - 694}
}
Perhaps the major frustration of the practising oncologist is his inability to prevent disease relapse in those common cancers where initial treatment with chemotherapy appears so effective. This emergence of resistance is the major cause of death in small cell lung cancer, breast cancer, ovarian cancer, acute leukaemia, and others. Strategies to overcome it, such as the use of alternating drug combinations, high dose chemotherapy and regional or targeted chemotherapy have met with limited… CONTINUE READING
34 Citations
17 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

Chromosal localisation of 3 genes coamplified in the multidrug resistant

  • J. L. BIEDLER
  • 1987

Expression of multidrug resistance gene in human tumours and tissus

  • J. H. GERLACH, J. A. ENDICOTT, P. F. JURANICA
  • Proc . Natl Acad . Sci .
  • 1987
1 Excerpt

Phosphorylation of the 170,000 to 180,000 glycoprotein specific to multi-drug resistant tumour cells: effects of verapamil, trifluoperazine and phorbol esters

  • H. HAMADA, HAGIWARA, K-I, T. NAKAJIMA, T. TSURUO
  • Cancer Res.,
  • 1987
1 Excerpt

The cell biology

  • W. T. BECK
  • 1987
2 Excerpts

Similar Papers

Loading similar papers…