The multidrug-resistance gene MDR1 is expressed in human glial tumors

@article{Becker1991TheMG,
  title={The multidrug-resistance gene MDR1 is expressed in human glial tumors},
  author={Ingeborg D Becker and K. -F. Becker and Richard Meyermann and Volker Hoellt},
  journal={Acta Neuropathologica},
  year={1991},
  volume={82},
  pages={516-519}
}
The most consistantly reported alteration of multidrug-resistant carcinoma cells is the overexpression of a membrane glycoprotein, termed P-glycoprotein. In this study we examined whether the strong intrinsic chemotherapy resistance of glial tumors might be related to the expression of the MDR1 gene which codes for P-glycoprotein. Fourteen glial tumors were examined immunohistochemically using the monoclonal antibody C219. In addition, RNA samples of 11 of these tumors were analysed using a… CONTINUE READING