The multicoloured world of promoter recognition complexes.

  title={The multicoloured world of promoter recognition complexes.},
  author={Ferenc M{\"u}ller and L{\'a}szl{\'o} Tora},
  journal={The EMBO journal},
  volume={23 1},
The expression pattern of regulated genes changes dynamically depending on the developmental stage and the differentiation state of the cell. Transcription factors regulate cellular events at the gene expression level by communicating signals to the general transcription machinery that forms a preinitiation complex (PIC) at class II core promoters. Recent data strongly suggest that PICs are composed of different sets of factors at distinct promoters, reflecting the spatiotemporal profile of… CONTINUE READING