The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.

@article{Spilman2014TheMD,
  title={The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.},
  author={Patricia Spilman and Olivier Descamps and Olivia F Gorostiza and Clare A. Peters-Libeu and Karen S. Poksay and Alexander Matalis and Jesus Campagna and Alexander Patent and Rammohan V Rao and Varghese John and Dale E. Bredesen},
  journal={Brain research},
  year={2014},
  volume={1551},
  pages={25-44}
}
Tropisetron was identified in a screen for candidates that increase the ratio of the trophic, neurite-extending peptide sAPPα to the anti-trophic, neurite-retractive peptide Aβ, thus reversing this imbalance in Alzheimer's disease (AD). We describe here a hierarchical screening approach to identify such drug candidates, moving from cell lines to primary mouse hippocampal neuronal cultures to in vivo studies. By screening a clinical compound library in the primary assay using CHO-7W cells stably… CONTINUE READING
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