The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.

@article{Borsutzky2005TheMA,
  title={The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.},
  author={Stefan Borsutzky and Karsten Kretschmer and Pablo D Becker and Peter F. M{\"u}hlradt and Carsten J Kirschning and Siegfried Weiss and Carlos Alberto Guzm{\'a}n},
  journal={Journal of immunology},
  year={2005},
  volume={174 10},
  pages={6308-13}
}
The macrophage-activating lipopeptide-2 (MALP-2) is an agonist of the TLR heterodimer 2/6, which exhibits potent activity as mucosal adjuvant, promoting strong humoral and cellular responses. Although B cells expressing TLR2/6 are potential targets, very little is known about the effect of MALP-2 on B cells. Studies were performed using total spleen cells or purified B cells from WT mice or animals deficient in TLR2, T cells, B cells, or specific subpopulations of B cells. They demonstrated… CONTINUE READING

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