The mucosal T cell integrin alpha M290 beta 7 recognizes a ligand on mucosal epithelial cell lines.

@article{Roberts1993TheMT,
  title={The mucosal T cell integrin alpha M290 beta 7 recognizes a ligand on mucosal epithelial cell lines.},
  author={Karen F Roberts and Peter J. Kilshaw},
  journal={European journal of immunology},
  year={1993},
  volume={23 7},
  pages={1630-5}
}
The integrin alpha M290 beta 7 is expressed at high levels on mucosal T cells, particularly on those within the epithelium of the gut. We now report that a mouse T cell hybridoma, MTC-1, with similar surface expression of this molecule, adhered strongly to cells of the mouse rectal carcinoma line CMT93 and that adhesion was blocked completely by the monoclonal antibody (mAb) M290. Other mAb to the alpha M290 or beta 7 subunits had little or no inhibitory effect. M290 also inhibited adhesion of… CONTINUE READING

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