The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study.

@article{Fiorentino2011TheMA,
  title={The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study.},
  author={David F. Fiorentino and Lorinda S Chung and Jeff Zwerner and Antony Rosen and Livia A. Casciola-Rosen},
  journal={Journal of the American Academy of Dermatology},
  year={2011},
  volume={65 1},
  pages={
          25-34
        }
}
BACKGROUND Dermatomyositis (DM) is a multisystem autoimmune disease, in which serologic evidence of immune responses to disease-specific antigenic targets is found in approximately 50% to 70% of patients. Recently, melanoma differentiation-associated gene 5 (MDA5) has been identified as a DM-specific autoantigen that appears to be targeted in patients with DM and mild or absent muscle inflammation and with an increased risk of interstitial lung disease. OBJECTIVE We wished to understand the… CONTINUE READING
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ANTI-MDA5-ASSOCIATED DERMATOMYOSITIS: EXPANDING THE CLINICAL SPECTRUM

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