The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia.

  title={The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia.},
  author={Ichiro Sora and Masahiko Funada and George R. Uhl},
  journal={European journal of pharmacology},
  volume={324 2-3},
Interactions between delta-opioid receptors and morphine-preferring mu-opioid receptor subtypes have been suggested. Availability of transgenic mu-opioid receptor knockout mice allows assessment of mu-opioid receptor roles in the analgesia produced by the classical delta-opioid receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in hot-plate and tail-flick tests. DPDPE analgesia was dramatically reduced in mu-opioid receptor knockout mice in a gene-dose-dependent fashion. The analgesia induced… CONTINUE READING

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