The mouse small ubiquitin-like modifier-2 (SUMO-2) inhibits interleukin-12 (IL-12) production in mature dendritic cells by blocking the translocation of the p65 subunit of NFκB into the nucleus.

@article{Kim2011TheMS,
  title={The mouse small ubiquitin-like modifier-2 (SUMO-2) inhibits interleukin-12 (IL-12) production in mature dendritic cells by blocking the translocation of the p65 subunit of NFκB into the nucleus.},
  author={Eun Mi Kim and Han-Hyoung Lee and Sang-Hoon Kim and Young-Ok Son and Suk Jun Lee and Jihye Han and Joonbeom Bae and S J Kim and Chung-Gyu Park and Yongsoo Park and Kwang Woo Hwang and Taehoon Chun},
  journal={Molecular immunology},
  year={2011},
  volume={48 15-16},
  pages={2189-97}
}
Post-translational modification by small ubiquitin-like modifier (SUMO) is involved in several significant cellular events. In particular, SUMO-1 and SUMO-4 modifications of IκBα have been shown to be actively involved in NFκB regulation. However, among the SUMO family, the specific function of SUMO-2/3 remains relatively unknown. In addition, it is not clear whether SUMO-2/3 follows the same functional role as SUMO-1 and SUMO-4 during the activation of NFκB. In this study, we examined the… CONTINUE READING

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