The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a.

@article{Jones2000TheMN,
  title={The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a.},
  author={Julie M. Jones and J. D. Huang and Valerie Mermall and Bruce A Hamilton and Mark S. Mooseker and Andrew Escayg and Neal G. Copeland and Nancy A. Jenkins and Miriam H. Meisler},
  journal={Human molecular genetics},
  year={2000},
  volume={9 5},
  pages={821-8}
}
Exon shuffling is thought to be an important mechanism for evolution of new genes. Here we show that the mouse neurological mutation flailer (flr) expresses a novel gene that combines the promoter and first two exons of guanine nucleotide binding protein beta 5 (Gnb5) with the C-terminal exons of the closely linked Myosin 5A (MyoVA) gene (Myo5a). The flailer protein, which is expressed predominantly in brain, contains the N-terminal 83 amino acids of Gnb5 fused in-frame with the C-terminal 711… CONTINUE READING