The mouse mammary gland requires the actin-binding protein gelsolin for proper ductal morphogenesis.

@article{Crowley2000TheMM,
  title={The mouse mammary gland requires the actin-binding protein gelsolin for proper ductal morphogenesis.},
  author={Michael R. Crowley and K. Larry Head and David J Kwiatkowski and Harold L. Asch and Bonnie B. Asch},
  journal={Developmental biology},
  year={2000},
  volume={225 2},
  pages={
          407-23
        }
}
Gelsolin is an actin-binding/severing protein expressed in intracellular and secreted forms. It is a major regulator of the form and function of the actin cytoskeleton in most all cells. Here we demonstrate that female mice with a targeted deletion of the gelsolin gene (Gsn-/-) have defects in mammary gland morphogenesis. Two distinct defects were identified in the gelsolin-null mammary gland. First, the mammary anlage from Gsn-/- mice failed to elongate at the onset of puberty and remained… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Similar Papers

Loading similar papers…