The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.

@article{Valarch1993TheMH,
  title={The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.},
  author={I Valarch{\'e} and Jean-Philippe Tissier-Seta and M R Hirsch and Salvador Martinez and Christo Goridis and Jean François Brunet},
  journal={Development},
  year={1993},
  volume={119 3},
  pages={881-96}
}
Transcriptional regulation of the gene encoding the cell adhesion receptor NCAM (neural cell adhesion molecule), a putative effector molecule of a variety of morphogenetic events, is likely to involve important regulators of morphogenesis. Here we identify two mouse homeodomain proteins that bind to an upstream regulatory element in the Ncam promoter: Cux, related to Drosophila cut and human CDP, and Phox2, a novel protein with a homeodomain related to that of the Drosophila paired gene. In… CONTINUE READING
97 Citations
68 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 97 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Similar Papers

Loading similar papers…