The mouse brown (b) locus protein has dopachrome tautomerase activity and is located in lysosomes in transfected fibroblasts.

@article{Winder1993TheMB,
  title={The mouse brown (b) locus protein has dopachrome tautomerase activity and is located in lysosomes in transfected fibroblasts.},
  author={Alison Winder and A Wittbjer and Elsa Rosengren and Hans Rorsman},
  journal={Journal of cell science},
  year={1993},
  volume={106 ( Pt 1)},
  pages={153-66}
}
Many genes mapping to pigmentation loci are involved in the regulation of melanin synthesis in the mouse. The brown (b) locus controls black/brown coat coloration, and its product has significant homology to the key melanogenic enzyme tyrosinase. This has led to suggestions that the b-protein is itself a melanogenic enzyme. In order to investigate its function, we have established lines of mouse fibroblasts stably expressing the b-protein by co-transfection of a b-protein expression vector and… CONTINUE READING

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