The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis.
@article{Habu1996TheMA, title={The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis.}, author={T. Habu and T. Taki and A. West and Y. Nishimune and T. Morita}, journal={Nucleic acids research}, year={1996}, volume={24 3}, pages={ 470-7 } }
Genetic recombination in meiosis plays an important role in generating diversity of genetic information. In yeast an Escherichia coli RecA-like gene, DMC1, is expressed in meiotic prophase and its product co-localizes with Rad51 protein on zygotene chromosomes. We have cloned the mouse and human homologs of the yeast DMC1 gene. The predicted human and mouse DMC1 proteins showed 54.1% sequence identity with yeast Dmc1 protein. The domain II region, highly conserved in the E.coli RecA-like… CONTINUE READING
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References
SHOWING 1-10 OF 65 REFERENCES
A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1993
- 160
- PDF
DMC1: A meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression
- Biology, Medicine
- Cell
- 1992
- 1,070
Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA
- Biology, Medicine
- Nature Genetics
- 1993
- 455
Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1995
- 573
- PDF
A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs.
- Biology, Medicine
- Nucleic acids research
- 1993
- 107
Nucleotide sequence and promoter analysis of SPO13, a meiosis-specific gene of Saccharomyces cerevisiae.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1990
- 78
- PDF
Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51.
- Biology, Medicine
- Molecular and cellular biology
- 1992
- 252
- PDF
Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
- Biology, Medicine
- Cell
- 1992
- 1,155
Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination
- Biology, Medicine
- Cell
- 1990
- 535
Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA.
- Biology, Medicine
- The EMBO journal
- 1994
- 438