The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis.

  title={The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis.},
  author={K. Yoshida and G. Kondoh and Y. Matsuda and T. Habu and Y. Nishimune and T. Morita},
  journal={Molecular cell},
  volume={1 5},
  • K. Yoshida, G. Kondoh, +3 authors T. Morita
  • Published 1998
  • Medicine, Biology
  • Molecular cell
  • The mouse Dmc1 gene is an E. coli RecA homolog that is specifically expressed in meiosis. The DMC1 protein was detected in leptotene-to-zygotene spermatocytes, when homolog pairing likely initiates. Targeted gene disruption in the male mouse showed an arrest of meiosis of germ cells at the early zygotene stage, followed by apoptosis. In female mice lacking the Dmc1 gene, normal differentiation of oogenesis was aborted in embryos, and germ cells disappeared in the adult ovary. Meiotic chromosome… CONTINUE READING
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