The mouse MPTP model: gene expression changes in dopaminergic neurons.

  title={The mouse MPTP model: gene expression changes in dopaminergic neurons.},
  author={Kati K{\"u}hn and Jennifer M Wellen and Nina M Link and Lyutha Maskri and Hermann Luebbert and Christine C. Stichel},
  journal={The European journal of neuroscience},
  volume={17 1},
Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Although valuable animal models have been developed, our knowledge of the aetiology and pathogenic factors implicated in PD is still insufficient to develop causal therapeutic strategies aimed at halting its progression. The neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most valuable models for… CONTINUE READING


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