The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns.

@article{Greally1998TheMH,
  title={The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns.},
  author={John M. Greally and Diana J. Starr and Seon-Kap Hwang and Lei Song and M Jaarola and Sharon Zemel},
  journal={Human molecular genetics},
  year={1998},
  volume={7 1},
  pages={91-5}
}
Genes subject to genomic imprinting generally occur in clusters of hundreds of kilobases. These domains exhibit several gamete of origin-dependent manifestations, including a pattern of asynchronous replication when studied by fluorescence in situ hybridization (FISH). We find a transition from asynchronous replication at the imprinted mouse H19 gene to synchronous replication at the downstream Rpl23 gene, the human homologue of which appears to be non-imprinted. Two-colour FISH demonstrates… CONTINUE READING
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