The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.

@article{Vitaterna2006TheMC,
  title={The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.},
  author={Martha H Vitaterna and Caroline H. Ko and A Chang and Ethan D. Buhr and Ethan M Fruechte and Andrew C Schook and Marina P. Antoch and Fred W Turek and Joseph S Takahashi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 24},
  pages={9327-32}
}
The mouse Clock gene encodes a basic helix-loop-helix-PAS transcription factor, CLOCK, that acts in concert with BMAL1 to form the positive elements of the circadian clock mechanism in mammals. The original Clock mutant allele is a dominant negative (antimorphic) mutation that deletes exon 19 and causes an internal deletion of 51 aa in the C-terminal activation domain of the CLOCK protein. Here we report that heterozygous Clock/+ mice exhibit high-amplitude phase-resetting responses to 6-h… CONTINUE READING
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Behavioral Neurobiology, Biological Rhythms, ed

  • J. T. Enright
  • Aschoff, J. (Plenum, New York),
  • 1981

Circular Statistics in Biology (Academic, London)

  • E. Batschelet
  • 1981

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