The most abundant glycoprotein of amebic cyst walls (Jacob) is a lectin with five Cys-rich, chitin-binding domains.

@article{Frisardi2000TheMA,
  title={The most abundant glycoprotein of amebic cyst walls (Jacob) is a lectin with five Cys-rich, chitin-binding domains.},
  author={Marta C. Frisardi and Sudip Ghosh and Jessica Field and Katrina L. Van Dellen and Rick Rogers and P E - Pathcentre Robbins and John Samuelson},
  journal={Infection and immunity},
  year={2000},
  volume={68 7},
  pages={4217-24}
}
The infectious stage of amebae is the chitin-walled cyst, which is resistant to stomach acids. In this study an extraordinarily abundant, encystation-specific glycoprotein (Jacob) was identified on two-dimensional protein gels of cyst walls purified from Entamoeba invadens. Jacob, which was acidic and had an apparent molecular mass of approximately 100 kDa, contained sugars that bound to concanavalin A and ricin. The jacob gene encoded a 45-kDa protein with a ladder-like series of five Cys-rich… CONTINUE READING

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