The morphology of synapses

@article{Peters1996TheMO,
  title={The morphology of synapses},
  author={Alan Peters and Sanford L. Palay},
  journal={Journal of Neurocytology},
  year={1996},
  volume={25},
  pages={687-700}
}
The word synapse was coined by Sir Charles Sherrington, in 1897, to denote the normal anatomical relation between contiguous neurons (see Foster & Sherrington, 1897). In a footnote in his textbook The Physiology of the Nervous System (Fulton, 1938, p. 55), Fulton reports that he had writ ten to Sherr ington to ask him about the origin of the word synapse and that in reply Sherrington had explained that when he came to describe the junction between nerve cells he felt the need of a specific new… 

Erratum to: Volume Electron Microscopy Study of the Relationship Between Synapses and Astrocytes in the Developing Rat Somatosensory Cortex.

Although synapses were randomly distributed in space, synapses that were free of astrocytic processes tended to form clusters, and at least in the developing rat neocortex, the concept of tripartite synapse only seems to be applicable to a subset of synapses.

Volume Electron Microscopy Study of the Relationship Between Synapses and Astrocytes in the Developing Rat Somatosensory Cortex

Although synapses were randomly distributed in space, synapses that were free of astrocytic processes tended to form clusters, and at least in the developing rat neocortex, the concept of tripartite synapse only seems to be applicable to a subset of synapses.

An Ultrastructural Study of the Thalamic Input to Layer 4 of Primary Motor and Primary Somatosensory Cortex in the Mouse

It is shown that, like sensory cortex (S1), mouse M1 also has the canonical circuit motif of a core thalamic input to the middle cortical layer and that thalamocortical synapses form a small fraction of all asymmetric synapses in L4 of both areas.

Area-specific synapse structure in branched axons reveals a subcellular level of complexity in thalamocortical networks

High-end 3D electron microscopy shows massive differences between MC vs. S1 Po synapses in a) bouton and active zone size; b) neurotransmitter vesicle pool size; c) mitochondria distribution near synapses; and d) proportion of non-spinous dendrite contacts.

Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses

It is concluded that the morphology and size of inhibitory post synapse specializations rather than differences in GlyR packing determine the postsynaptic strength of glycinergic neurotransmission in motor and sensory spinal cord networks.

Form, synapses and orientation topography of a new cell type in layer 6 of the cat’s primary visual cortex

The results suggest an integrating role for the layer 6 stellate neuron which projects to a functionally broad range of neurons in the deep cortical layers and to other cortical and/or subcortical regions.
...

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