The morphology of smoke inhalation injury in sheep.

@article{Hubbard1991TheMO,
  title={The morphology of smoke inhalation injury in sheep.},
  author={Gene B. Hubbard and P C Langlinais and Takeshi Shimazu and Carlin Vance Okerberg and Arthur D. Mason and Basil A. Jr. Pruitt},
  journal={The Journal of trauma},
  year={1991},
  volume={31 11},
  pages={
          1477-86
        }
}
Pulmonary injury resulting from inhalation of chemical and particulate products of incomplete combustion is one of the principal determinants of mortality following burn injury. In this study, the histopathology of inhalation injury was examined in sheep. Mild, moderate, or severe smoke injury was produced in anesthetized sheep by insufflation with various doses of ambient temperature smoke, generated by burning polyethylene, wood pulp, and nonwoven cellulose pads. A total of 64 sheep were… 
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Effects of rolling inhibition on smoke inhalation injury.

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Results suggest that strategies to remove or decrease formation of upper airway obstructive material may reduce its deposition into small airways and parenchyma and may improve respiratory function in victims of smoke inhalation injury.

Inhalation injury and burn trauma: an experimental investigation of oxidative stress and histopathology

Evidence is provided that inhalation injury with and without burn decrease tissue antioxidant capacity and increase tissue peroxidative injury.

Assessment of oxidative stress in lungs from sheep after inhalation of wood smoke.

Smoke inhalation enhances early alveolar leukocyte responsiveness to endotoxin.

Smoke inhalation induces a massive influx of alveolar leukocytes that are primed for an early, enhanced LPS-activated cytokine response compared withAlveolarLeukocytes isolated after burn injury alone or normal controls.

A model of recovery from inhalation injury and cutaneous burn in ambulatory swine.

AEROSOLIZED TISSUE PLASMINOGEN INHIBITOR IMPROVES PULMONARY FUNCTION IN SHEEP WITH BURN AND SMOKE INHALATION

Evidence is provided that clearance of airway obstructive cast material is crucial in managing acute respiratory distress syndrome resulting from combined burn and smoke inhalation injury.

Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation.

It is suggested that H2S exerts protective effects in acute lung injury, at least in part through the activation of anti-inflammatory and antioxidant pathways.

Pathophysiological Basis of Smoke Inhalation

The bronchial circulation contributes to edema formation in the lung that occurs after ALI caused by smoke inhalation injury, and this phenomenon has been confirmed by other investigators.

PULMONARY EXPRESSION OF NITRIC OXIDE SYNTHASE ISOFORMS IN SHEEP WITH SMOKE INHALATION AND BURN INJURY

The study indicates that in uninjured sheep lung, endothelial (eNOS) is constitutively expressed in the endothelial cells associated with the airways and parenchyma, and in macrophages.
...

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