The morphologic similarities of human and canine globoid leukodystrophy. Thin section and freeze-fracture studies.

@article{Yunis1976TheMS,
  title={The morphologic similarities of human and canine globoid leukodystrophy. Thin section and freeze-fracture studies.},
  author={Edmond J. Yunis and Richard E. Lee},
  journal={The American journal of pathology},
  year={1976},
  volume={85 1},
  pages={
          99-114
        }
}
Human and canine globoid leukodystrophy are shown to be indistinguishable morphologically. Both have characteristic deposits with polygonal cross-sectional profiles in addition to twisted ribbon-like structures. The specificity of the deposits is emphasized, and their laminated nature is corroborated by the freeze-fracture studies. Their apparently hollow profiles in cross section are thought to be produced by the tight arrangement of the bilayers that prevent penetration of the stain.