The morphogenesis of mouse vallate gustatory epithelium and taste buds requires BDNF-dependent taste neurons.

@article{Oakley1998TheMO,
  title={The morphogenesis of mouse vallate gustatory epithelium and taste buds requires BDNF-dependent taste neurons.},
  author={Bruce Oakley and Adam Brandemihl and Deyna Cooper and David Lau and Alexander R. Lawton and Chenggang Zhang},
  journal={Brain research. Developmental brain research},
  year={1998},
  volume={105 1},
  pages={85-96}
}
The developmental absence of brain-derived neurotrophic factor (BDNF) in null mutant mice caused three interrelated defects in the vallate gustatory papilla: sparse innervation, a reduction in the area of the gustatory epithelium, and fewer taste buds. On postnatal day 7, the stunted vallate papilla of bdnf null mutant mice was 30% narrower, the trench walls 35% reduced in area, and the taste buds 75% less abundant compared with wild-type controls. Quantitative assessment of innervation density… CONTINUE READING
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