The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

@article{Pola2001TheMS,
  title={The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors},
  author={Roberto Pola and Leona E. Ling and Marcy Silver and Michael J. Corbley and Marianne Kearney and Robert Blake Pepinsky and Renee Shapiro and Frederick R. Taylor and D. P. 7326 Baker and Takayuki Asahara and Jeffrey M. Isner},
  journal={Nature Medicine},
  year={2001},
  volume={7},
  pages={706-711}
}
Sonic hedgehog (Shh) is a prototypical morphogen known to regulate epithelial/mesenchymal interactions during embryonic development. We found that the hedgehog-signaling pathway is present in adult cardiovascular tissues and can be activated in vivo. Shh was able to induce robust angiogenesis, characterized by distinct large-diameter vessels. Shh also augmented blood-flow recovery and limb salvage following operatively induced hind-limb ischemia in aged mice. In vitro, Shh had no effect on… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
258 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 258 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration

  • Wang, L.C
  • J. Invest. Dermatol
  • 2000

Insights in to early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in type and mutant zebrafish embryos

  • Brown, L.A
  • Mech. Dev
  • 2000

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

  • Stone, D.M
  • J. Cell
  • 1999

Similar Papers

Loading similar papers…