The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons

@article{Yasuda2009TheMS,
  title={The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons},
  author={Shigeru Yasuda and M-H Liang and Zoya Marinova and Amir Yahyavi and D. C.-C. Chuang},
  journal={Molecular Psychiatry},
  year={2009},
  volume={14},
  pages={51-59}
}
Brain-derived neurotrophic factor (BDNF) has been strongly implicated in the synaptic plasticity, neuronal survival and pathophysiology of depression. Lithium and valproic acid (VPA) are two primary mood-stabilizing drugs used to treat bipolar disorder. Treatment of cultured rat cortical neurons with therapeutic concentrations of LiCl or VPA selectively increased the levels of exon IV (formerly rat exon III)-containing BDNF mRNA, and the activity of BDNF promoter IV. Surprisingly, lithium- or… CONTINUE READING
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