The monothiol glutaredoxin Grx4 exerts an iron-dependent inhibitory effect on Php4 function.


When iron is scarce, Schizosaccharomyces pombe cells repress transcription of several genes that encode iron-using proteins. Php4 mediates this transcriptional control by specifically interacting with the CCAAT-binding core complex that is composed of Php2, Php3, and Php5. In contrast, when there is sufficient iron, Php4 is inactivated, thus allowing the… (More)
DOI: 10.1128/EC.00060-12