The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats?

@article{Combe2004TheMI,
  title={The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats?},
  author={Rachel Combe and Steve Bramwell and Mark J. Field},
  journal={Neuroscience letters},
  year={2004},
  volume={370 2-3},
  pages={236-40}
}
Osteoarthritis (OA) is a widespread condition affecting the elderly population. One of the most prominent features but least studied symptoms is chronic pain associated with OA. The study objective was to determine pain endpoints in rats with monosodium iodoacetate (MIA) induced OA, and to investigate the efficacy of common nociceptive agents. Sprague-Dawley rats received an intraarticular injection of either 25 microl 80 mg/ml MIA or 25 microl 0.9% sterile saline into the right knee joint… CONTINUE READING
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