The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.

@article{Ghosh2013TheML,
  title={The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.},
  author={Sudeshna Ghosh and Laura E. Wise and Yugang Chen and Ramesh Gujjar and Anu Mahadevan and Benjamin F Cravatt and Aron H. Lichtman},
  journal={Life sciences},
  year={2013},
  volume={92 8-9},
  pages={498-505}
}
AIM The present study tested whether the selective monoacylglycerol lipase (MAGL) inhibitor JZL184 would reduce allodynia and paw edema in the carrageenan test. MAIN METHODS The anti-edematous and anti-allodynic effects of JZL184 were compared to those of PF-3845, an inhibitor of fatty acid amide hydrolase (FAAH), and diclofenac, a non-selective cyclooxygenase inhibitor. Cannabinoid receptor involvement in the anti-edematous and anti-allodynic effects of JZL184 was evaluated by administration… CONTINUE READING

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