The molecular understanding of osteoclast differentiation.

  title={The molecular understanding of osteoclast differentiation.},
  author={Masataka Asagiri and Hiroshi Takayanagi},
  volume={40 2},
Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor (NF)-kappaB ligand (RANKL), as well as macrophage colony-stimulating factor (M-CSF). Congenital lack of osteoclasts causes osteopetrosis, investigation of which has provided insights into the essential molecules for osteoclastogenesis, including TNF receptor-associated… CONTINUE READING
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