The molecular switch hypothesis fails to explain the inconsistent effects of the metabotropic glutamate receptor antagonist MCPG on long-term potentiation.


In the CA1 region of the hippocampus, the induction of long-term potentiation (LTP) appears to be controlled by a switch-like biochemical process that is persistently activated following metabotropic glutamate receptor (mGLUR) activation. However, the mGLUR antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) does not consistently block the induction… (More)


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