The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase.


BACKGROUND The intestinal parasitic worm, Ascaris suum, produces a variety of protein inhibitors that defend the organism against the host's proteinases. Eight different proteins from Ascaris suum have been identified as inhibitors of serine proteinases, targeting chymotrypsin, elastase and trypsin. These inhibitors share 30-40% sequence identity with one… (More)


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