Highly Influenced
9 Excerpts
The molecular structure of the Toll-like receptor 3 ligand-binding domain.
- Published 2005 in Proceedings of the National Academy of Sciences…
Abstract
Innate immunity is the first line of defense against invading pathogens. Toll-like receptors (TLRs) act as sentinels of the innate immune system, sensing a variety of ligands from lipopolysaccharide to flagellin to dsRNA through their ligand-binding domain that is composed of leucine-rich repeats (LRRs). Ligand binding initiates a signaling cascade that… (More)