The molecular sources of reactive oxygen species in hypertension.

  title={The molecular sources of reactive oxygen species in hypertension.},
  author={Paolo Puddu and Giovanni Maria Puddu and Eleonora Cravero and Marzia Rosati and Antonio Muscari},
  journal={Blood pressure},
  volume={17 2},
In both animal models and humans, increased blood pressure has been associated with oxidative stress in the vasculature, i.e. an excessive endothelial production of reactive oxygen species (ROS), which may be both a cause and an effect of hypertension. In addition to NADPH oxidase, the best characterized source of ROS, several other enzymes may contribute to ROS generation, including nitric oxide synthase, lipoxygenases, cyclo-oxygenases, xanthine oxidase and cytochrome P450 enzymes. It has… CONTINUE READING