The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium.

@article{Oudit2001TheMP,
  title={The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium.},
  author={Gavin Y. Oudit and Zamaneh Kassiri and Rajan Sah and Rafael J Ramirez and Carsten Zobel and Peter H. Backx},
  journal={Journal of molecular and cellular cardiology},
  year={2001},
  volume={33 5},
  pages={
          851-72
        }
}
G. Y. Oudit, Z. Kassiri, R. Sah, R. J. Ramirez, C. Zobel and P. H. Backx. The Molecular Physiology of the Cardiac Transient Outward Potassium Current (I(to)) in Normal and Diseased Myocardium. Journal of Molecular and Cellular Cardiology (2001) 33, 851-872. The Ca(2+)-independent transient outward potassium current (I(to)) plays an important role in early repolarization of the cardiac action potential. I(to)has been clearly demonstrated in myocytes from different cardiac regions and species… 

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TLDR
Contrary to previous gene transfer studies involving the Kv4.3 current, the response of guinea pig ventricular myocytes to a fully inactivating I(to) is similar to that of canine ventricular cells and in animals such as dogs that have a broad cardiac action potential, I( to) does not play a major role in setting the APD.
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TLDR
It is concluded that PC I (to) shows significant differences from VM I(to), with some features, such as tetraethylammonium sensitivity, that have been reported in neither cardiac I( to) of atrial or ventricular myocytes nor cloned K(+) channel subunits known to participate in cardiac I-to.
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TLDR
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TLDR
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TLDR
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TLDR
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