The molecular pathology of rosacea.

Abstract

Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all related by the presence of chronic facial skin inflammation. Until recently, the pathophysiology of this disease has been poorly understood and limited to descriptions of factors that exacerbate or improve this disorder. Recent molecular studies suggest that an altered innate immune response is involved in the pathogenesis of the vascular and inflammatory disease seen in patients with rosacea. These findings may help explain the benefits of current treatments and suggest new therapeutic strategies helpful for alleviating this disease. This article discusses the possible molecular mechanisms for the pathogenesis of rosacea from current clinical observations and laboratory research.

DOI: 10.1016/j.jdermsci.2009.04.007
010020030020102011201220132014201520162017
Citations per Year

1,038 Citations

Semantic Scholar estimates that this publication has 1,038 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Yamasaki2009TheMP, title={The molecular pathology of rosacea.}, author={Kenshi Yamasaki and Richard L Gallo}, journal={Journal of dermatological science}, year={2009}, volume={55 2}, pages={77-81} }